In Professor Xuecai Ge ’s lab, where UC Merced researchers study how cells talk to each other to develop and differentiate, a recent surprise discovery is lending insight as to how erroneous cell signals lead to disease and birth defects.
Ge and her colleagues zeroed in on a slice of the communication system, the primary cilia, and found a protein called Numb, which they didn’t expect to be there.
Numb facilitates development of the spinal cord and cerebellum during embryonic neurodevelopment.